The functionality of nearly any biomedical system can be traced down to an intricate and complex system of interacting molecules, operating under chemical and physical principles, that ultimately drives biological phenomena, from the microscale to the macroscale. And this is the approach that we take as we seek to develop solutions to relevant issues in modern medicine that have not yet been fully resolved - protein folding disorders, mechanisms of cell signaling, pathogen antibiotic resistance, enzymatic catalysis, just to name a few. Our research collaborations are driven by these pressing questions in molecular and cell biology, and are tackled from both computational and empirical grounds. We see tremendous potential in the parallel usage of tools from biochemistry/structural biology, computational modeling, and organic chemistry in developing new knowledge of the molecular systems that drive human health. We seek aspiring biomedical researchers who are unafraid to tackle intellectually challenging problems with enthusiasm, curiosity, and creativity to push forwards the limits of molecular medicine. We hope you will join us this summer in #ASDRP2021.
Amyloid Inhibitors of Aβ-42 Towards Developing Therapeutic Strategies for Alzheimer's Disease
Aggregation of the peptide Aβ-42 has been linked to progression of Alzheimer's disease. We are interested in natural product screening and nature-inspired synthetic compounds that inhibit aggregation of amyloid fibrils. Further, we employ various computational methods to understand the biophysical parameters behind amyloid formation.
Structure-Activity Relationships in Small Molecule Antibiotic Compound Development
Sulfa antibiotics have been previously shown to be competitive inhibitors of dihydropteroate synthase (DHPS), which is integral in the biosynthetic pathway of folic acid in many prokaryotes. Here, we investigate structure-activity relationships in a synthetic library of novel small molecules in antimicrobial activity.
Molecular Oncology: Pharmacophores in Tubulin-Binding Antiproliferative Agents
Several natural product have been shown to attenuate the growth of tumor cells by blocking mechanisms of the mitotic spindle in rapidly dividing cells. Here, we incorporate natural product screening and de novo molecular design to engineer the next generation of potentially antiproliferative agents towards anti-cancer drugs.
Total Synthesis of Etoposide and Anti-Tumor Activity of Etoposide Analogs
Etoposide is a clinically used drug that treats a variety of cancer types by inhibiting the action of topoisomerase during DNA replication. Here, we describe a synthetic route towards etoposide, and the design and development of etoposide analogs as potential anti-cancer pharmaceuticals.
Development of a Machine Learning Platform towards Antiviral Therapy Discovery
This project is jointly handled by computer science and biochemistry research students. We are working on a machine learning platform for rapid screening of small molecule non-nucleoside antiretroviral inhibitors of the reverse transcriptase enzyme of the Human Immunodeficiency Virus (HIV).
Biologics Design, Discovery, and Development towards potential COVID-19 therapies
A collaboration of research advisors are collectively using virtual screening means and molecular biology tools to identify and develop biologics such as siRNA therapies as well as antiretroviral drug repurposing in efforts of accelerating preclinical drug discovery against SARS-CoV2 (novel coronavirus, 2019). Since ASDRP operates at a Biosafety Level 1, no live/actual coronavirus specimens will be handled.
Development of novel inhibitors of TP53 Induced Glycolysis Regulatory Phosphatase (TIGAR)
A collaboration of research advisors (Brah, Tallapaka, Gupta, Njoo) are using computational biophysical models, small molecule screening, and enzyme kinetics to identify small molecule inhibitors of TP53 Induced Glycolysis Regulatory Phosphatase (TIGAR), which has been linked to the replication of cancer cells. There are currently no known inhibitors of TIGAR.
Synthesis and in vivo screening of novel benzimidazoles as KRas inhibitors
This work in collaboration between the Clark and Brah groups is currently involved in indium-catalyzed oxidative condensations towards novel benzimidazoles as KRAS inhibitors for cancer therapy.
What We Do
Biomedical research is interdisciplinary - we are huge fans of combining the best techniques and approaches across the life sciences towards understanding some of the most pressing issues in molecular medicine today.
Leadership & Investigators
The Biomedical Research Cluster is composed of several research faculty members from all three departments (Biology, Chemistry, CS/Engineering) who are involved in cross-disciplinary work that has potential application and impact in the biomedical field.
Guest Speakers and Seminars
08.02.2020 Biomed Guest Speaker: Edie Zusman, MD
Join us this Sunday at 2-3 PM for our final summer Biomed Guest Speaker Seminar hosted by Ankur Gupta, Director of Biomedical Research. Our guest speaker this week is Dr. Edie Zusman, Chief of Neurosurgery at North Point Healthcare. Click here for details.
07.26.2020 Biomed Guest Speaker: Sethu Sankaranarayanan, PhD
Join us this Sunday at 2-3 PM for our third summer Biomed Guest Speaker Seminar hosted by Ankur Gupta, Director of Biomedical Research. Our guest speaker this week is Dr. Sethu Sankaranarayan, a neuroscientist at Annexon Biosciences. Dr. Sankaranarayanan will be sharing his academic journey as a scientist as well as some of the recent science that has been developing in molecular neuroscience and neurodegenerative disease targeted research. Click here for details.
07.19.2020 Biomed Guest Speaker: Tony Qu
Join us this Sunday at 2-3 PM for our third summer Biomed Guest Speaker Seminar hosted by Ankur Gupta, Director of Biomedical Research. Our guest speaker this week is Tony Qu, PhD candidate at the University of California, San Francisco. Mr. Qu currently performs research at UCSF on craniofacial sciences. Click here for details.
07.12.2020 Biomed Guest Speaker: Kristen Valentine
Join us this Sunday at 2-3 PM for our second summer Biomed Guest Speaker Seminar hosted by Ankur Gupta, Director of Biomedical Research. Our guest speaker this week is Dr. Kristen Valentine, a research fellow at the La Jolla Institute of Allergy and Immunology. Dr. Valentine obtained her PhD in immunology from the University of California, Merced - and will be sharing some of the latest frontiers in the field. Click here for details.
07.05.2020 Biomed Guest Speaker: Jimmy Qian
Join us this Sunday at 2-3 PM for our first summer Biomed Guest Speaker Seminar hosted by Ankur Gupta, Director of Biomedical Research. Our first guest speaker is Jimmy Qian, MD candidate and venture capitalist at Stanford Medicine and co-founder of Osmind, and a board member at ASDRP. Click here for details.