Every week, some of our senior researchers in each department at ASDRP give public seminar presenting the current state of the field, and disseminating how their research at ASDRP fits into the broader context of the frontiers of modern science and engineering. Colloquia are public events, and anyone can join. Simply click the Google Calendar link to add the event to your calendar.
Department of Chemistry, Biochemistry & Physics
Fridays @ 8:00 - 9:00 PM PST
Friday, January 8, 2021
Green Approaches to and virtual hit-to-lead generation of synthetic monoterpenoid nonucleoside reverse transcriptase inhibitors towards the development of novel HIV antiretroviral therapies .
nt is a major contributor of waste in organic synthesis, so the greenness of a chemical reaction can be improved by changing the solvent. The oxidation of (-)-menthol to (-)-menthone in different solvent systems was monitored using Fourier-transform infrared (FTIR) spectroscopy. Our study conducted this reaction in solvent systems of acetic acid and other solvents as replacements for acetonitrile: acetone, ethyl acetate, and dichloromethane. Solvent choice was determined based on the principles of green chemistry, and kinetics and yield of the reactions in different solvents were investigated. Menthol was used a core scaffold for novel non-nucleoside reverse transcriptase inhibitors against HIV-1 reverse transcriptase. HIV is a member of Retroviruses, the class of viruses that function through insertion of their genetic material into the host cell’s DNA. This is made possible by the enzyme reverse transcriptase which allows for the reverse transcription of RNA to DNA and thus allows for the viral integration into the host cell’s genetic code. Menthol was selected due to its chiral nature, in an attempt to recreate a butterfly structure similar to first-generation NNRTIs.
Arti S., Quarry Lane School
Njoo Research Group
Organic, Medicinal Chemistry
Department of Computer Science & Engineering
Wednesdays @ 8:00 - 9:00 PM PST
Wednesday, January 6, 2021
Use of Unruh DeWitt Detectors and Tpx3Cam to understand Spatial Entanglement from a Quantum Field Theory Perspective.
Albert Einstein once referred to Quantum Entanglement as the "spooky action at a distance". Quantum entanglement is the phenomenon where two particles are connected to each other, such that some of their properties are identical. We look to understand how the spatial distance, or how far away the entangled particles are, affects the entanglement dynamics, such as the strength of entanglement. To better understand this, we will try to get two diverse understandings, one mathematical, another experimental. Our first, more mathematical approach will be to understand how Unruh DeWitt Detectors predict the entanglement dynamics based on whether the detectors are in each other's light cone. Our second, more experimental approach will be to look at how the TPX3Cam describes the strength of entanglement based on the time difference of the detection of entangled photons from a SPDC photon source. We will then compare both of our perspectives to get a better understanding of how the spatial distance between two entangled particles affects the entanglement dynamics.
Modakar K., Quarry Lane School
Diptanshu S., BASIS Independent H.S.
Ananya B., W. Windsor Plainsboro HS N.
McMahan Research Group