Every week, some of our senior researchers in each department at ASDRP give public seminar presenting the current state of the field, and disseminating how their research at ASDRP fits into the broader context of the frontiers of modern science and engineering. Colloquia are public events, and anyone can join. Simply click the Google Calendar link to add the event to your calendar.
Department of Chemistry, Biochemistry & Physics
Fridays @ 8:00 - 9:00 PM PST
Friday, January 29, 2021
Synthetic versatility of β-ketoesters: Multicomponent Biginelli cyclocondensation reactions provide inroads for rapid access to privileged scaffolds in medicinal chemistry for anti-cancer drug discovery.
As cancer is currently the second highest leading cause of death with no true cure, many researchers around the world are seeking to conduct cancer research in the hopes of developing new treatments and therapeutics capable of combating this disease. Many of the successful small molecule therapeutics for cancer have been the products of years of intensive drug discovery research, involving the use of high throughput virtual screening, biological screening, and chemical synthesis. Specifically, multicomponent reactions (MCRs) are incredibly useful in drug discovery, offering relatively basic methods for the discovery of combinatorial products and the ability to produce large libraries. Due to the recently discovered pharmacological properties associated with dihydropyrimidines, the multicomponent Biginelli reaction has had a resurgence in scientific interest. Here, an overview of the prevalence of β-ketoesters and MCRs and our work in the laboratory will be discussed along with a review of general progress in the field.
Krithikaa P., Doughtery Valley High School
Njoo Research Group
Organic, Medicinal Chemistry