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Student Colloquia

Every week, some of our senior researchers in each department at ASDRP give public seminar presenting the current state of the field, and disseminating how their research at ASDRP fits into the broader context of the frontiers of modern science and engineering. Colloquia are public events, and anyone can join. Simply click the Google Calendar link to add the event to your calendar.

Department of Biological, Human & Life Sciences

Tuesdays @ 8:00 - 9:00 PM PST

Tuesday, February 2, 2021

 

 

 

 

 

Department of Chemistry, Biochemistry & Physics

Fridays @ 8:00 - 9:00 PM PST

Friday, February 5, 2021

Comparative singlet oxygen photosensitizer efficiency of berberine, rose bengal, and methylene blue by time course nuclear magnetic resonance (NMR) monitoring of a photochemical 4+2 cycloaddition endoperoxide formation .

Berberine, a natural product alkaloid, has been shown to exert biological activity via in situ production of singlet oxygen, a highly reactive oxygen species when photo irradiated. Berberine utilizes singlet oxygen in its putative mechanism of action, wherein it forms an activated complex with DNA and photosensitizes triplet oxygen to singlet oxygen to specifically oxidize guanine residues, halting cell replication, leading to cell death. This has potential application in photodynamic therapy, alongside other such compounds, which also act as photosensitizers and produce singlet oxygen in situ. In this study, berberine's singlet oxygen production was compared against two known photosensitizers, methylene blue and rose bengal, to determine berberine’s efficacy as a singlet oxygen photosensitizer. Singlet oxygen production can be monitored by trapping the reactive oxygen species with a diene via a 4+2 Diels Alder-like cycloaddition reaction, and resulting endoperoxide can be quantified using 1H nuclear magnetic resonance (NMR) spectroscopy. The quantification of singlet oxygen production can direct the future synthesis of berberine analogs and identify medicinally significant singlet oxygen photosensitizers.  

 

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Sophie P., Carlmont High School

​Njoo Research Group

Organic, Medicinal Chemistry

Department of Computer Science & Engineering

Wednesdays @ 8:00 - 9:00 PM PST

Wednesday, February 3, 2021

 

 

 

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Past Colloquia

Week of  January  24, 2021

Week of  January  17, 2021

Week of  January  10, 2021

Week of  January  3, 2021

Week of  December 13, 2020

Week of December 6, 2020

Week of November 29, 2020

Week of November 22, 2020

Week of November 15, 2020

Week of November 8, 2020

Week of November 1, 2020

Week of October 25, 2020

Life Science Research & Development Laboratory:

46307 Warm Springs Blvd. Fremont, CA 94539

Engineering Research Laboratory:

46249 Warm Springs Blvd. Fremont, CA 94539

General Inquiries: asdrp.admin@asdrp.org

Admissions: admissions@asdrp.org

Telephone: 1(510)371-4831

© Aspiring Scholars Directed Research Program 2021, All rights reserved.

ASDRP is a production of Olive Children Foundation, a 501(c)(3) nonprofit organization in Fremont, California.

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