Every week, senior researchers in each department at ASDRP give public seminars presenting the current state of the field and disseminating how their research at ASDRP fits into the broader context of the frontiers of modern science and engineering. Colloquia are public events, and anyone can join. Click on the "Join the Colloquia" link to add the event to your calendar.
Department of Biological, Human and Life Sciences
Tuesdays @ 8:00-9:00 PM PST
Tuesday, June 22, 2021
No Colloquia this week - please check back for more info
See you next week!
Researcher: To Be Announced
Advisor: To Be Announced
Department of Chemistry, Biochemistry, and Physics
Fridays @ 8:00-9:00 PM PST
Friday, June 25, 2021
Informed synthetic design and mechanistic assaying of photoreleasable prodrugs and andrographolide analogs for enhanced therapeutic potential
Semisynthetic derivatives of natural products far outnumber the amount of actual natural products in clinical use. One such natural product is andrographolide, which has demonstrated diverse therapeutic potential such as anticancer, antifungal, and antioxidant properties, but may be further optimized for human use. Alongside enhancing the efficacy of therapeutic agents, it is equally important to find ways to minimize post-administration side effects, which is why various prodrugging tactics have been employed in the past two decades. Prodrugs are benign derivatives of active drugs, which may be activated under certain conditions like pH, light, hydrolysis, or enzymatic conversion. This presentation will cover the rational design and semisynthesis of a library of analogues derived from the natural product andrographolide to optimize its therapeutic potential, as well as discuss how substitutions on the photocleavable o-nitrobenzyl functional group may enhance targeted photorelease of the surrogate drug phenylacetic acid.
Researchers: Alice Z., BASIS Independent Silicon Valley
Advisor: Njoo, Organic & Medicinal Chemistry
Keywords: Organic Synthesis | Chemical biology | Andrographolide | Prodrugs
Department of Computer Science and Engineering
Wednesdays @ 8:00-9:00 PM PST
Wednesday, June 23, 2021
Using abnormalities in NASA's stellar radius measurements to predict the location of possible mini-black holes.
Black holes are mysterious phenomena that occur in space, and it has captivated astronomers for decades. The reason black holes are so mysterious is because they are unable to observed directly due to the fact that this region of spacetime's gravity consumes all light that travels toward it. This means that black holes have to be discovered indirectly in some way, and a way scientists have been doing so is by using the strange behavior of the celestial bodies that surround black holes. This research focuses on the discovery of mini-black holes, a category of black holes that are less massive than normal. This type of black hole exhibits the strange behavior of pulling on nearby stars, making them oblate. Here, data from the NASA Exoplanet Archive will be used to find stars possibly stretching in that way, which could give clues for a possible location of a mini-black hole.
Researcher: Ishaan K., Milpitas High School
Advisor: Downing, Astrophysics
Keywords: Exoplanet Archive | Mini black holes | Data analysis